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Babe Ruth was born George Herman Ruth, Jr. at his grandparents' house at 216 Emory Street in Baltimore, Maryland. His parents were George Herman Ruth and Kate Schamberger Ruth. The house where Babe Ruth was born is now the site of the Babe Ruth Birthplace and Museum which opened to the public on July 20, 1974.

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George Herman Ruth Jr. was born in Baltimore, Maryland, on Feb. 6, 1895 to Kate Schamberger Ruth and George Herman Ruth Sr.

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His parents put in long hours tending tavern, and Babe's mother was often ill. This meant that Babe was pretty much left to raise himself on the Baltimore streets. On June 13, 1907, when Babe Ruth was seven years old, his father placed him in St. Mary's Industrial School for Boys, a Catholic orphanage and reformatory, ran by the Xaverian Brothers. Babe rarely saw his family. His parents never came to the school, and he was only allowed to return home once a year for a visit. At St. Mary's, Babe received an education, worked in the school's shirt-making shop, and played baseball. The Ruth’s had eight children but only two survived infancy, Babe and his sister, Mamie

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Other players on the Baltimore Orioles, who were the minor league team for the Boston Red Sox, saw him and they called him “Jack’s newest babe.” He was signed to a contract by Jack Dunn who owned and managed the Orioles.

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While Babe Ruth was playing baseball at St. Mary's, he came to the attention of Jack Dunn, owner and manager of the International League team, the Baltimore Orioles, and Dunn offered Babe a contract. The Xaverian Brothers signed custody of 19-year old Babe Ruth over to Jack Dunn, making him Babe's legal guardian. Babe only played six months with the Orioles before he signed with the Boston Red Sox.

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Babe Ruth began playing for the Boston Red Sox on July 14, 1914. He pitched left and played the outfield. 

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Babe Ruth married a 17-year old waitress, Helen Woodford, in October 1914.

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In October of 1914, Babe Ruth married Helen Woodford. By 1925, the couple had separated but remained married because of their religious beliefs. Helen Ruth died in a house fire in 1929, and Babe married Claire Hodgson on April 1, 1929.

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George Herman "Babe" Ruth died at Memorial Hospital in New York City when he was 53 years old.

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Babe Ruth was 53 years old when he died of throat cancer on Aug. 16, 1948. An estimated 100,000 people came to pay their respects as his body lay in state at the entrance of Yankee Stadium on Aug. 17th and 18th.